Dr. Matt Zierhut and Dr. John Maringwa chat about the PSP special collection on Model-Based Meta-Analysis (MBMA), how it extends traditional meta-analysis, and how it supports predictive modeling, synthetic controls, and go/no-go decisions. They discuss integrating MBMA with quantitative systems pharmacology (QSP), combining aggregate and individual patient data, key tutorials and education efforts, reporting practices that improve MBMA, and priorities for potential regulatory guidance.
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